Weboxathiaphospholane (OTP) method for the stereocontrolled synthesis of PS-DNA, employing chro-matographically separated, diastereomerically pure 5'-O-DMT-nucleoside-3'-O-(2-thio-1,3,2-OTP) monomers and 1,4-diazabicyclo[5.4.0]undec-7-ene (DBU) as an activator, has been developed (Scheme 1, DMT = 4, 4'-dimethoxytrityl) [33–35]. WebMay 24, 2004 · A 1,3,2-oxathiaphospholane ring-opening condensation method was also used for the synthesis of mixed backbone phosphate/phosphorothioate 2 oligonucleotides and [ 18 O]-labelled isotopomeric oligonucleotides. 3 Condensation of 5′- O -DMT-thymidine 3′- O - (2-seleno-1,3,2-oxathiaphospholane) with 3′- O -acetylthymidine in the presence of …
Oxathiane - Wikipedia
WebSep 23, 2006 · 1,3,2-oxathia-phospholane or -phosphorinane 2-sulfide derivatives 2 and 3 are readily accessible by reaction of the triethylammonium salts 1 of diesters of the phosphorotetrathioic acid with ω-bromo alcohols under mild conditions. Key Words: Oxathiaphospholane derivatives oxathiaphosphorinane derivatives phosphorotetrathioic … WebВы можете найти все продукты в Jinan Sanbao Biotechnology Co., Ltd., включая английское название продукта, китайское название, номер CAS и молекулярное выражение. mavericks game tonight dallas channel
Oxathiaphospholane Method of Stereocontrolled …
WebJan 30, 2001 · Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope Piotr Guga Dr. , Centre of Molecular and Macromolecular Studies Polish Academy of Sciences Department of Bioorganic Chemistry Sienkiewicza 112, 90-363 Łódź, Poland, … WebJan 6, 2024 · In this study, we present a new selenium derivative, 2'-deoxyguanosine-5'-O-selenophosphate (dGMPSe), synthesized by the oxathiaphospholane method and adapted here for the synthesis of nucleoside selenophosphates.Using biochemical assays (HPLC- and fluorescence-based), we investigated the enzymatic activity of HINT1 towards … Weboxathiaphospholane derivatives (OTP-GN0) containing a second stereogenic center at the phosphorus atom. These monomers were chromatographically separated intoP-diastereoisomers, which were further used for the synthesis of P-stereodefined “dinucleoside” phosphorothioates GN PST(G N¼ GA, GC, GG, GT). mavericks gas station careers