Hybrid mouse diversity panel hmdp strains

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August undefined, 2024

Web4 jul. 2024 · For our studies, we selected the HMDP, a cohort of more than 100 genetically diverse inbred mouse strains that allows high-resolution genetic mapping, replication, and multi-omics analyses in the ... Webrience with the HMDP, describe various ongoing projects, and discuss how the HMDP may ﬁt into the larger picture of common diseases and different approaches. Overview of the HMDP The hybrid mouse diversity panel (HMDP) consists of a population of over 100 inbred mouse strains selected for usage in systematic genetic analyses of complex …

Genetic Architecture of Noise-Induced Hearing Loss: Evidence …

WebMost basic and translational studies utilize only a single inbred mouse strain. However, basal and diseased immune states in humans show vast inter-individual variability. Here, … WebThe Institutional Care and Use Committee (IACUC) at University of Southern California endorsed the animal protocol for the Hybrid Mouse Diversity Panel (HMDP) inbred strains (IACUC 12033). Strains and genotypes are accessible from Jackson Labs ( www.jax.org). queen of barks llc

The Hybrid Mouse Diversity Panel: a resource for systems genetics ...

WebAbstract The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and … Web15 aug. 2012 · In the current HMDP panel consisting of over 100 inbred and RI strains, we used ~860,000 SNPs to examine linkage disequilibrium (LD) blocks. These SNPs have … Web30 apr. 2024 · Abstract This is the first genome-wide association study (GWAS) with the Hybrid Mouse Diversity Panel (HMDP) to define the genetic landscape of the auditory hair cell synapse and the... shipper\u0027s b8

Genetic Architecture of Heart Mitochondrial Proteome influencing ...

WebTo enable well-powered studies in mice, high-density genotypes for inbred strains of mice using the Mouse Diversity Array are generated, which increase marker density by 1.9-fold, have reduced missing data rates, and provide more accurate identification of heterozygous regions compared with previous genotype data. Human genome-wide association … WebOver the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes, and have shown that the … shipper\u0027s b9http://zarlab.cs.ucla.edu/tag/hmdp/ queen of assyria

"Web24 jul. 2024 · Here, focusing on macrophage responses to lipopolysaccharide (LPS), we use the hybrid mouse diversity panel (HMDP) of 83 inbred strains as a surrogate for … " - Hybrid mouse diversity panel hmdp strains

Hybrid mouse diversity panel hmdp strains

Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A …

Web15 aug. 2012 · Map of linkage disequilibrium (LD) blocks along the genome in the hybrid mouse diversity panel (HMDP) population. The LD blocks were determined using … Web23 dec. 2024 · Using the Hybrid Mouse Diversity Panel (HMDP), we sought to identify the genetic determinants of airway hyperreactivity (AHR) in response to diesel exhaust …

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Web7 nov. 2016 · The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and … Web5 feb. 2024 · Microarray data generated from WAT of mice in the Hybrid Mouse Diversity Panel (HMDP) were correlated with other transcripts and strain phenotypes, as previously described . Correlations were analyzed as a midweight bicorrelation, and all data were significant at a false discovery rate (FDR) of 5%.

Web1 nov. 2016 · However, because a CSS panel is derived from just two mouse strains, they have less genetic diversity relative to CC, HMDP, and OS. Another problem is that if a QTL has been identified in a particular chromosome, further fine mapping is generally needed to narrow down the QTL, through the construction of congenic strains ( DeSantis et al. … Web15 aug. 2012 · The hybrid mouse diversity panel (HMDP) consists of a population of over 100 inbred mouse strains selected for usage in systematic genetic analyses of complex traits (Table 1).Our goals in selecting the strains were to (1) increase resolution of genetic mapping, (2) have a renewable resource that is available to all investigators worldwide, …

Web24 dec. 2024 · Hybrid Mouse Diversity Panel (HMDP), we sought to identify the genetic determinants of airway hyperreactivity (AHR) in response to diesel exhaust particles (DEP), a model traffic-related air pollutant. As measured by invasive plethysmography, AHR under control and DEP-exposed conditions varied 3-4-fold in over 100 inbred strains from the … Web18 feb. 2024 · We examined natural genetic variation in lipopolysaccharide (LPS)-induced PD across a panel of inbred mouse strains, the hybrid …

http://zarlab.cs.ucla.edu/tag/hmdp/

Web31 mrt. 2024 · In this body of work, male C57BL/6J mice with humanised lipid profiles, via transgenic expression of the human cholesteryl ester transferase protein (CETP) transgene (Jiang et al., 1992) and the human apolipoprotein (APO)E*3-Leiden variant (van den Maagdenberg et al., 1993), were interbred with female HMDP mice to generate a panel … queen of basketball diesWeb31 jul. 2024 · We examined an isoproterenol heart failure model across a panel of diverse inbred strains of mice, the Hybrid Mouse Diversity Panel (HMDP), using left atrial (LA) and lung weights as well as echocardiogram parameters as surrogates for cardiac diastolic function. We identified gene transcripts that significantly correlated with diastolic function. queen of aquaria sotteotWebfemale mice of ~100 strains included in the hybrid mouse diversity panel (HMDP) and compared the NAFLD molecular pathways and gene networks between sexes. Results: We identified both shared and sex-specific biological processes for … queen of banshees smiteWebSuch strains can expand the HMDP panel to more than 260 strains. Recombinant inbred congenic, consomic and Genome Tagged Mice ( Peters et al. 2007) can also be added. As mentioned earlier, HMDP data can be integrated with that from other panels, notably the Collaborative Cross. queen of basketball lusia harrisWeb7 nov. 2016 · The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. queen of bacchanalWebDuring the past 10 years, we have developed a unique mapping approach in mice that is analogous to genome-wide association studies in humans. This approach utilizes a well … shipper\u0027s baWeb5-week old female mice (n=695) from 111 Hybrid Mouse Diversity Panel strains (n= 6-7/strain) were purchased from Jackson Laboratories. A detailed characterization of the … shipper\\u0027s bb