Web31 de mar. de 2024 · Other investigations have corroborated the inhibitory effects of phytochemicals on HIF-1 in control of glucose metabolism. For instance, methylalpinumisoflavone (MF) (PubChem CID: 15596285), a … Web1 de ago. de 2024 · After stroke, HIF-1 can induce the expression of EPO to enhance oxygen delivery and promote cell survival by inducing the expression of genes related to energy metabolism. Also, HIF-1 helps maintain the stability of the intracellular environment via upregulating NCX1 and promotes neovascularization by inducing the expression of …
The effect of HIF on metabolism and immunity - Nature
Web3 de jun. de 2024 · The current knowledge of hypoxic cell metabolism and regulation of HIF1 activity provides a strong basis for the development of future therapies designed to … Web21 de mai. de 2024 · HIF1 activation led to a slowly retinal degeneration in the aging mouse retina, and inhibiting HIF1α can mitigate this degeneration. Kusunose N, et al. Jpn J Ophthalmol. 2024 The clock gene DEC2 modulated HIF1 protein levels and upregulated VEGF mRNA in human cell line of retinal glial cells. D’Amico AG, et al. J Cell Physiol. 2024 shy02.cc
Hepcidin, a key regulator of iron metabolism and mediator of …
Web30 de out. de 2024 · Therefore, our work identified ACSL1 as a HIF-1-target gene that drives lipid metabolism. The results also suggest that the FABP5/HIF-1α axis can be used to … Web14 de ago. de 2008 · The transcription factor hypoxia-inducible factor 1 (HIF1) has been implicated in regulating many of the genes that are responsible for the metabolic … Web16 de jun. de 2024 · Semenza, G. L. HIF-1 mediates the Warburg effect in clear cell renal carcinoma. ... Denko, N. C. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 8, 705–713 (2008). shy09