Growth arrest specific 6

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August undefined, 2024

WebGrowth arrest-specific 6 (Gas6) encodes the Gas6 protein that binds to TAM receptors (Tyro3, Axl, Mer), resulting in PI3K and Akt pathway activation. 224,225 In platelets, this Gas6 plays a critical role in outside-in signaling, as … WebApr 21, 2024 · In the journal Nature [1], an international research group recently published data on a cellular and molecular mechanism that links stress hormones produced by adrenal glands to the activation of...

Gas6 ameliorates intestinal mucosal immunosenescence to …

WebHere, we tested the hypothesis that expression of growth arrest–specific 6 (GAS6), the ligand of receptor tyrosine kinase AXL, is associated with chemotherapy response and that sequestration of GAS6 with AVB-S6–500 (AVB-500) could improve tumor response to chemotherapy and PARP inhibitors. morsetto phoenix

Gas6 expression is reduced in advanced breast cancers

WebApr 4, 2024 · Gas6 growth arrest specific 6 [ (house mouse)] Gene ID: 14456, updated on 22-Jan-2024. Summary. Enables receptor ligand activity. Acts upstream of or within … WebNov 16, 2015 · What Is New? Growth arrest–specific 6 (GAS6) is upregulated in failing human hearts, pressure overload–induced murine hypertrophic... For the first time, … WebFeb 24, 2005 · The growth arrest-specific gene 6 ( Gas-6) is a secreted vitamin K-dependent protein, which binds the receptor tyrosine kinases Axl (also called Ark, Ufo), Sky (also called Rse, Tyro3, Dtk), and C-Mer (also … minecraft schematic howling blade

Targeting GAS6 in cancer, fibrosis and viral infection - Drug …

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Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts. See more Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation. See more Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3. The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues … See more • Maree AO, Jneid H, Palacios IF, Rosenfield K, MacRae CA, Fitzgerald DJ (2007). "Growth arrest specific gene (GAS) 6 modulates … See more WebGAS6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. GAS6 has a high structural homology with the natural anticoagulant … minecraft schematic file viewerWebType 2 diabetes mellitus (T2DM) is a major global health issue. The development of T2DM is gradual and preceded by the pre-diabetes mellitus (pre-DM) stage, which often remains undiagnosed. This study aimed to identify novel pre-DM biomarkers in a high-fat diet (HFD)-induced pre-DM mouse model. Male C57BL/6J mice were fed either a chow diet or HFD … morse trichoptera

"http://www.informatics.jax.org/marker/MGI:95660 " - Growth arrest specific 6

Growth arrest specific 6

GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to …

WebGrowth arrest-specific gene 6 (Gas6) belongs to the family of vitamin K-dependent coagulation proteins, but in contrast to its other members, has only a limited role in hemostasis. Instead, Gas6 plays a prominent role in conditions of injury, inflammation and repair. Gas6 amplifies the activation of various cell types including endothelial ... WebAim: Gas6 is known to be elevated in sepsis, correlating with the severity of infection and organ failure. We aimed to investigate the performance of Gas6 plasma levels at admission to predict the risk of mortality in a cohort of septic

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WebGrowth arrest specific 6 (GAS6) encodes a protein that serves as a ligand for AXL receptor tyrosine kinase and stimulates cell proliferation. Notably, an antisense RNA, namely GAS6-AS1 is transcribed from chromosome 13q34, near GAS6 gene. In vitro functional experiments have demonstrated that GAS6-A … WebSep 27, 2024 · Excessive endothelial cell stretch causes release of Growth Arrest Specific 6 (GAS6), which activates the tyrosine kinase receptor Axl on monocytes and promotes immune activation and inflammation ...

WebIn this review, we summarize three important emerging VKDPs: Growth arrest‑specific protein 6 (Gas 6), Gla‑rich protein (GRP) and periostin in terms of their functions in physiological and pathological conditions. As examples, carboxylated Gas 6 and GRP effectively protect blood vessels from calcification, Gas 6 protects from acute kidney ... WebFind Mice (IMSR) 24 strains or lines available. Comparison Matrix. Gene Expression + Phenotype. Homozygous null mice are protected against arterial and venous …

WebJan 12, 2024 · Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein related to inflammation, fibrosis, as well as platelet function. Genetic ablation of GAS6 in mice protects against cardiac hypertrophy and dysfunction. Nonetheless, the association between plasma GAS6 levels and acute heart failure (AHF) patients is still unknown. We measured … Webpointed to a secreted protein called growth arrest-specific 6 (GAS6) as a candidate molec - ular messenger. Indeed, delivering GAS6 into the skin using an adenovirus vector (a com-mon tool in gene therapy) not only stimulated hair growth in normal mice, but also restored hair growth during chronic stress or cortico-sterone feeding.

WebAn Overview for Parents: Growth arrest can occur as a result of trauma, metabolic disorders, malnutrition and underlying skeletal dysplasias. Any disruption or injury to the …

WebApr 24, 2024 · Growth arrest-specific gene 6 (Gas6) is a cytokine that binds to receptor tyrosine kinases Tyro3, Axl, and Mer. Numerous studies have suggested that macrophage-derived Gas6 interacts with... minecraft schematics asian styleWebMar 4, 2015 · Growth Arrest-Specific 6 (GAS6) is a vitamin K-dependent protein (VKDP) which is expressed by diverse tissues such as endothelial cells, smooth muscle cells, … minecraft schematics airshipWebアズワンの【AXEL】84-4418-23 GAS6 (Growth Arrest Specific Protein 6, AXLLG, AXSF, AXL Stimulatory Factor, AXL receptor tyrosine kinase ligand) 200ul 363225のコーナーです。AXELは研究開発、医療介護、生産現場、食品衛生など幅広い分野に750万点以上の品揃えでお応えする商品サイト。3000円以上ご注文で送料無料。 morse truckingWebPlasma protein growth arrest-specific 6 (GAS6) and matrix Gla protein (MGP) are crucial mediators of vascular calcification and are involved in the development of vascular complications in chronic kidney diseases. This study was set out to morse \u0026 the last endeavourWebJan 20, 2024 · Here, we show that growth arrest-specific 6 (Gas6), released by intestinal macrophages that recognize K. pneumoniae , inhibits bacterial invasion into the intestinal epithelium and subsequent translocation to the liver. However, in elderly mice, Gas6 is hardly secreted due to decreased intestinal mucosal macrophages; therefore, K. … morse tv locationsWebJan 3, 2024 · We revealed that growth arrest specific 6 (GAS6), a ligand of the TYRO3–AXL–MERTK signaling system, plays a critical role in this process. Upon birth, microorganisms residing in the oral cavity induce expression of GAS6 in oral tissues; GAS6 in turn regulates antibacterial function in these tissues. morse trucking morseWebgrowth arrest specific 6. Synonyms. Gas-6, GAS 6, growth arrest-specific Feature Type. protein coding gene. IDs. MGI:95660 NCBI Gene: 14456. Alliance. gene page. Transcription Start Sites. 4 TSS. Location & Maps more. Sequence Map Chr8:13515374-13544490 bp, - strand. From Ensembl annotation of GRCm39 ... morse tz.50 sewing machine