Chip and atherosclerosis
WebFeb 29, 2016 · In conclusion, the developed atherosclerosis-on-a-chip mimics a physiologically-relevant 3D stenotic blood vessel which enables long-term perfusion cell culture and on-chip visualization of ... WebAtherosclerosis is closely related to vascular dysfunction and hypertension. Ojeoksan (OJS), originally recorded in an ancient Korean medicinal book named “Donguibogam”, is a well-known, blended herbal formula. This study was carried out to investigate the beneficial effects of OJS on atherosclerosis in vitro and in vivo. Western-diet-fed apolipoprotein-E …
Chip and atherosclerosis
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WebNov 17, 2024 · Interestingly, CHIP is determined by mutations in a handful of genes, which are currently under active investigations in experimental models. For example, accelerated atherosclerosis and increased release of inflammatory cytokines have been found in mice that bear TET2-deficient leukocytes. WebSep 14, 2024 · The biology of atherosclerosis comes full circle: lessons for conquering cardiovascular disease. Atherosclerosis causes myocardial infarction, ischaemic cardiomyopathy, many ischaemic strokes and ...
WebJun 1, 2024 · Microfluidic models of atherosclerosis: replacing animal testing with on-chip technology ... However, for atherosclerosis and many other diseases, many aspects of the pathology are still being elucidated, 2 supporting the need for in vitro models that can rapidly be redesigned to investigate the latest findings. For example, current clinical ...
Web19 hours ago · CHIP indicates clonal hematopoiesis of indeterminate potential; LDL, low-density lipoprotein; and Nrf2, nuclear factor-erythroid-2–related factor 2. ... disease. 35 The endothelium and medial layer of the vessel wall are affected in part by similar processes contributing to atherosclerosis and arteriosclerosis. 36 As patients with CKD are at ... WebJan 19, 2024 · To mimic the human scenario of clonal hematopoiesis and test whether clonal expansion of TET2-deficient hematopoietic cells contributes to atherosclerosis, we used a competitive bone marrow transplantation (BMT) strategy to generate atherosclerosis-prone, low-density lipoprotein receptor–deficient (Ldlr −/−) chimeric …
WebFeb 4, 2024 · For example, Zheng et al. leveraged this device design to simultaneously apply fluid shear stress and cyclic stretch to endothelial cells to recapitulate the mechanical conditions associated with early atherosclerosis (Zheng et al., 2016). They found an increase in reactive oxygen species formation in response to either abnormal fluid shear …
WebPrevious studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifying each of these cell types. Here, using Myh11-CreER(T2) ROSA floxed STOP eYFP … song lyrics somebody to loveWebOct 6, 2024 · The potential exists to alter the course of atherosclerosis with anti-inflammatory drugs. With increased understanding of the specific mechanisms that regulate the relationship between inflammation and atherosclerosis, new, more effective and specific anti-inflammatory treatment may become available. ... (CHIP). An initial … song lyrics something told the wild geeseWebOct 5, 2024 · It’s caused by inflammation in the arteries. Atherosclerosis is a type of arteriosclerosis, a condition in which your arteries become stiff. Arteriosclerosis is caused by elastin fibers in your ... song lyrics some people call me mauriceWebSep 1, 2024 · Current Atherosclerosis Reports - Clonal hematopoiesis of indeterminate potential (CHIP) ... CHIP is a cardiovascular risk factor of increasingly recognized … smallest iphone screen sizeWebFeb 7, 2024 · CHIP carriers also had increased coronary artery calcification, a marker of coronary atherosclerosis. These CHIP variants, as well as the DNA damage response … song lyrics something like a phenomenonWebAug 16, 2024 · Atherosclerosis, the formation of fibrofatty lesions in the artery wall, causes much morbidity and mortality worldwide, including most myocardial infarctions and many strokes, as well as disabling peripheral artery disease. Development of atherosclerotic lesions probably requires low-density lipoprotein, a particle that carries cholesterol ... smallest iphone standWeb1 hour ago · Data are mean ± SD. Change was defined as the value at 12 months minus the value at baseline. †p < 0.05; †††p < 0.001. Thousands of kidney care professionals will … song lyrics somewhere out there